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Even though choline is produced endogenously in the liver, it is still considered an essential nutrient because the quantities produced is not sufficient to meet the body's metabolic needs
The inclusion of benzyl alcohol helps reduce contamination risk during multiple withdrawals while supporting long-lasting usability under appropriate handling conditions

However, genetic factors also play a role in their development

elegans , and mammalian cells resulted in increased mitochondrial function and biogenesis, UPR mt , and antioxidant response gene expression 108110