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This deactivation of MKPs allows for the unimpeded progression and sustained activation of the pro-inflammatory ERK1/2, JNK, and p38 signaling cascade within the MAPK pathway (Son et al., 2011)

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This cardiotoxicity is associated with increased expression of muscle ring finger-1 (MuRF1), a ubiquitin ligase involved in muscle atrophy

Hence, these efforts underscore the importance of TXNRD as a potential therapeutic target for cancer
