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EZN-2208 ( 3b ) is a TPT- congener, its high lipid solubility as a PEGylated analog of SN38 ( 3c ), the active metabolite of irinotecan (Camptosar CPT-11, 3d ) 55 , have improved its pharmacokinetic and antitumor properties in preclinical models of solid tumors and lymphomas 56

doi: 10.1038/s41598-022-06476-1

This is particularly beneficial for adults over 65 and those with problems or previous surgery in the digestive tract

The results from Fischer and his colleague suggested that H3K4me3 is actually not an optimal marker of active promoters and that the activating effect mainly results from its frequent colocalization with acetylations [27]