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NFE2L2 is typically destined to be ubiquitinated by Kelch-like ECH-associated protein 1 (Keap1), a component of the Cullin 3 (CUL3)-based E3 ubiquitin ligase complex, and is degraded by the ubiquitinproteasome pathway within the cytoplasm [42]
bioRxiv 2025 Oct 9:2025.10.08.681007
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L-glutamine not only provides the source of energy for the intestinal epithelium, it also helps maintain the structural integrity of the gut epithelial cells and TJ development [70]
