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Certain bulk drug substances for use in compounding that may present significant safety risks
Although ROS generated under physiological conditions are not harmful, and likely play a signaling role, toxic or pathological conditions that lead to an impairment of mitochondrial function can increase the release of ROS
HIF-1 is upregulated in various human cancers and plays a key role in driving tumor growth, invasion and metastasis
PMID 11158675
