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The presence of unprotected peptide bonds at both the N- and C-terminal linkages predicts that Norleual should have poor metabolic stability and rapid clearance for the circulation, properties that may limit its clinical utility

(Luke Turnock, a sociologist at the University of Lincoln, in England, has described this phenomenon as folk pharmacology.) Michaels foot pain improved, but, strangely, he also noticed that his skin was changing color