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Palomina-Schatzlein et al

10.1074/jbc.RA119.009548 115 NunomuraA.MoreiraP
Auria BioBank samples were coded and accompanied with information about gender, age, diagnosis and time interval between diagnosis date and sample collection

It is most often based on the clinical symptoms together with laboratory assessment (low serum vitamin B 12 level and elevated serum homocysteine or methylmalonic acid level) and the response to treatment to make definitive diagnosis
