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3 Chrono-Exposome and aging The concept of the chrono-exposome encompasses the cumulative impact of environmental stressors on homeostatic processes throughout an individuals life, particularly through their effects on the circadian system and, consequently, on the physiological functions it regulates

Sci Rep (2019) 9(1):111

Consequently, Wnt inhibitors such as Dickkopf agonist investigated in vitro are considered promising in hyperpigmentation treatment (Supplementary information 6.3) [30, 184, 185]

GSSSG deactivates the NF-B signaling pathway, which results in downregulation of proinflammatory gene expression in retinal cells including microglia