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Although it has been demonstrated that FOXO4-DRI has a strong preference for targeting senescent cells [24], because different organs or tissues have different drug sensitivities, the safety and tolerability of FOXO4- DRI must be considered

Biomedicines 10:945 Saxena M, Burke A, Pavlick A, Blazquez A, Gimenez G, Meseck M, Donovan M, Rodriguez D, Castillo-Martin M et al (2022) Abstract CT108: immunogenicity of poly-ICLC matured dendritic cells as an adjuvant for NY-ESO-1 and Melan-A-MART-1 peptide vaccination compared to Montanide ISA-51 VG, in study subjects with melanoma in complete clinical remission but at high risk of disease recurrence

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This pattern holds biological significance in PD in that it suggests that disease- or treatment-related effects may exert selective pressure on the microbial network in the gut without necessarily lowering the overall number of microbial species present, thereby exerting an influence on GBA signaling and L-DOPA metabolism