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Abstract Background Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-survival pathways dependent on endoplasmic reticulum (ER)

The presence of high levels of neurotransmitters stimulates various monoamine receptors located in the postsynaptic membrane

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