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Description
Thymosin alpha-1 is often considered the most logical starting point due to its well-established safety profile, its direct immune-modulatory mechanism, and the finding that lupus patients tend to have lower endogenous levels
Alford DP, Compton P, Samet JH
Common forms of epigenetic modifications encompass DNA modifications, noncoding RNA modifications, and histone modifications
Tumor heterogeneity represents another limitation, as mutations or non-genetic mechanisms leading to NRF2 activation are not uniformly present across HCC subtypes
