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If a patient cant tolerate allopurinol and meets the criteria (see above) for probenecid, that can be tried

Lysosome ROS has been identified as a causative agent in lysosomal rupture, a phenomenon typically associated with the later stages of necrosis [189]

10.1007/BF02979058 16 BairdL.YamamotoM

Results were considered statistically significant at p 80%) and concerns regarding imprecision and risk of bias were the main factors contributing to downgrading (Supplementary Table S3)
