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This is not just a figure of speechit is the gut-brain axis in action

In summary, the impairment of System Xc - function significantly enhances ferroptosis sensitivity in drug-resistant cancers, offering a promising therapeutic target for overcoming chemoresistance.Notably, certain drug-resistant cancer cells can counteract System Xc- inhibition by activating alternative cysteine acquisition pathways, such as the transsulfuration pathway mediated by cystathionine -synthase (CBS) or direct cysteine uptake via ASCT transporters (52)

It is important to note that in this study, the medications were stored in a controlled environment in the original unopened bottle and not under real-world conditions

Ferroptosis is a newly identified form of nonapoptotic programmed cell death characterized by iron-dependent accumulation of lipid peroxides, and has drawn wide attention since the term was put forward in 2012 [25]