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The smaller clearance compared with the expected value of 5.5 L/h may reflect additional renal functional impairment due to heart failure

At therapeutic doses in healthy individuals, glutathione regenerates

This is highlighted by the crystal structures of the Mn II -sensing (Figure 22C) 609 and Ni II /Co II -sensing riboswitches (Figure 22D)

27:1529-1540 Maya B L (2010) Endocrine side effects of broad-acting kinase inhibitors