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Proc Natl Acad Sci USA 104: 1934519350 Dunlop PC, Roon RJ (1975) Lasparaginase of Saccharomyces cerevisiae : an extracellular enzyme

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This is not always the case with dermal fillers and is not true of Voluma

doi: 10.1053/j.gastro.2013.05.048
