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doi: 10.1615/critrevoncog.v12.i1-2.20 35 FreitasMCayuelaCAntoineJMPillerFSapinCTrugnanG

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Overall, the gasdermin-mediated pore formation is a pivotal step in pyroptosis execution, integrating signals from classical inflammasome pathways and apoptotic caspases, and its modulation in melanoma has significant implications for therapeutic strategies aimed at inducing immunogenic cell death ( Figure 2 ) (71, 72)