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That kickstarts the immune system, which revs up CD38 activity, creating a vicious cycle: more inflammation, more CD38, less NAD
Also, glutamate excitotoxicity, itself, forms fragmented mitochondria, contributing to oxidative stress through the dysfunctional mitochondria (80)
10.1093/bioinformatics/8.3.275 Bioinformatics 31 Jubany-MariT.Munne-BoschS.Lopez-CarbonellM.AlegreL
Li, Z., Okamoto, K
