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Ea este sintetizata in ficat si in rinichi, in biosinteza ei fiind necesare vitaminele C, B6 si diferite enzime

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Moreover, recent study found that hypoxia-inducible factor (HIF)1 and HIF-2 in GBM cells jointly mediate upregulation of the mRNA and protein expression levels of the BCAAs transporter LAT 1 and the BCAAs metabolizing enzyme BCAT1, and ultimately promote the growth of cells under hypoxia conditions