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However, these strains show more severe hemorrhage caused by sinusoidal endothelial cell (SEC) damage [99, 129], which may aggravate the hepatocellular injury due to microcirculatory disturbances leading to additional ischemic necrosis [95, 129, 130]

Conditions associated with altered glutamate homeostasis include drug addiction, chronic pain, depression, schizophrenia, and neurodegenerative disorders [107], suggesting potential applications for NAC as adjuvant therapy in these disorders