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A major component of the evidence that implicates lipids in AD pathogenesis is the presence of the APOE 4 genetic allele, which represents the highest genetic risk factor for late-onset AD (281283)

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In another study, oral administration of curcumin (100 mg/kg/day) for 7 days protected purkinje neurons with the amelioration of motor function and reduction of cerebellar atrophy in rat model of cerebellar ataxia, challenged with neurotoxin 3-acetylpyridine (Mahmoudi et al

Veterinary Pathology 22: 610-616.Google Scholar CYR, D.M., EGAN, S.G., BRINI, C.M
