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This is especially true for gastrointestinal issues such as: Acid reflux Gastric irritation Ulcer-related discomfort Animal studies on gastric ulcers have shown visible healing within 7 to 14 days, with significant reduction or complete closure of lesions

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doi: 10.3389/fimmu.2017.00023

For this reason, its always preferable to use biologically active formulations of B12 even if you dont know your MTHFR defect status
