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The mismatch repair-dependent DNA damage response: mechanisms and implications

Several studies have identified essential roles for glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the generation of precursors for ribonucleotide synthesis, and thereby, nucleic acid synthesis ( Figure 1 Magnetic resonance spectroscopy (MRS) is a method of interrogating metabolism in a non-invasive manner in cells, animals and human patients ( 1 H MRS monitors steady-state metabolite levels while 13 C MRS monitors metabolic fluxes

doi: 10.1111/jgs.14909 9

rhamnosus Distinguished by its tolerance to extreme GI pH gradients, this species is also industrially significant for driving organoleptic changes in cheese maturation ( 3.1.3 Lactobacillus fermentum Characterized by high auto-aggregation and adhesive capacity, strain JDFM216 exhibits strong anti-infective and antioxidant properties ( 3.1.4 Lactobacillus johnsonii Exemplified by the seminal strain LA-1, this species is noted for its resilience to bile and antibiotics ( 3.1.5 Lactococcus lactis A primary species in probiotic research, specific strains like ML-2018 demonstrated potent anti-inflammatory activity by downregulating LPS-induced cytokines ( 3.1.6 Lactobacillus reuteri This species offers a broad therapeutic spectrum, ranging from urogenital health and dental caries prevention to the management of infantile colic ( 3.2 Bifidobacterium species: therapeutic and functional profiles The genus Bifidobacterium comprises a diverse group of probiotic bacteria critical for maintaining GI homeostasis and developing functional therapeutic applications ( Table 2 )