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This would result in an estimated annual burden of this final change of 3,564 hours (1,782 2) at a cost of $442,221 (3,564 $124.08)

2 More recently, an Atmospheric Pressure Gas Chromatography (APGC) system was developed by McEwen, 3 then at DuPont (Wilmington, DE)

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)