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Since GSTO1 overexpression has been implicated in drug resistance, particularly to platinum compounds 7,18,19 , we tested the effects of GSTO1 inhibitors in combination with cisplatin in HCT116 cells

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Many studies have demonstrated the importance of the Nrf2/ARE pathway in the pathogenesis and control of neurological disorders, including PD, AD, ischemia, and other neurodegenerative diseases

To validate this interaction, GST pull-down assays were performed and confirmed direct binding of HMGB1/2 to SLIT2-N terminal (N) and SLIT2-C terminal (C), with K-Hcy modification enhancing HMGB1/2 and SLIT2-N interaction strength