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10.1083/jcb.131.3.775 59 PalmrR.MenpJ.JauhiainenA.LarssonB.MoJ.RussellM.et al (2018)

One drink early in the evening One standard drink consumed 4 to 6 hours before bed produces a measurable but modest effect on slow-wave sleep and a small dip in nocturnal GH amplitude
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Nitration can significantly modify the structure and function of proteins in cells

Your age, activity level, and physical health may also be factors
