menadione glutathione Schematic diagram of cellular response to in the presence or * Without enough glutathione Menadione USP testing specifications meets

doi: 10.1007/s11010-019-03667-9 119 ZhangJBaoYZhouXZhengL

Their beneficial mechanisms can include the attenuation of neuroinflammation [e.g., valproate via histone deacetylase (HDAC) inhibition in microglia, downregulating interleukin-1 beta (IL-1) and inducible nitric oxide synthase (iNOS)] or the mitigation of glutamatergic excitotoxicity coupled with enhancement of neurotrophic factor expression (e.g., lamotrigine), thereby conferring antidepressant-like potential (Mula and Sander, 2007

TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma

Supports Brain Function Because oxidative stress is linked to cognitive decline, glutathiones protective effects can also benefit brain health