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Description
From the results of both drugs in clinical trials and those approved for market use, it is evident that despite ongoing research and new drug developments, the clinical translation of therapies for NAFLD/NASH faces numerous challenges
Preclinical studies indicate that metformin promotes M2 macrophage polarization through STAT6 activation, which facilitates tissue repair and attenuates TGF-1-mediated renal fibrosis (109)

10.1016/j.jtho.2019.04.007 J
Birmes P, Coppin D, Schmitt L, Lauque D
