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584 Similarly, miR-21 downregulates the human DNA MutS homolog 2 (hMSH2) in CRC cells, thereby inducing resistance to 5-FU
10.1016/j.gie.2018.08.006 47
During aging, there is a decrease in biological functions and in the ability to adapt to metabolic stress
Finally, we review the therapeutic implications of these discoveries with the use of both epigenetic clocks as predictors and the development of epidrugs that target the DNA methylation/demethylation machinery
