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In the Sibutramine Cardiovascular Outcomes (SCOUT) trial, the drug was shown to be associated with increased risk of major adverse cardiovascular events (a composite of non-fatal heart attack, non-fatal stroke, resuscitation after cardiac arrest, and cardiovascular death) in obese patients, as compared to placebo [29]

A similar frequency of infections was found in a retrospective, multicenter, observational study of 104 individuals with molecularly confirmed Wiedemann-Steiner syndrome (195)