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Reduced mRNA transcription activity was evident by the down-regulation of genes governing UTP synthesis ( pyrABCFH ), uracil import ( pyrP ), and the expression of RNA polymerase subunits ( rpo )

doi: 10.1006/gcen.1993.1146 126 MorleyJEMelmedSBriggsJCarlsonHEHershmanJMSolomonTEet al

As a result, there has been a corresponding increase in the number of clinical trials being conducted globally, with many countries investing in research and development to address the growing demand

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