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Most interestingly, the steatosis observed in EtOH-fed WT mice was absent from KO mice (Fig

This transition from hydrophobic to hydrophilic state initially weakens the hydrophobic stabilization and subsequently the newly introduced carboxyl groups interfere with electrostatic interactions

Studies from mouse models have revealed that the transcriptional profile of the rod-shaped microglia was akin to that of DAM (Matsuba et al., 2025) and that rod-shaped microglia interact with neuronal dendrites, attenuate motor cortical hyperactivity during an early stage of TDP-43-associated neurodegeneration (Xie et al., 2025)