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[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Bauman J.E., Hsu C.H., Centuori S., Guillen-Rodriguez J., Garland L.L., Ho E., Padi M., Bageerathan V., Bengtson L., Wojtowicz M., et al

However, markedly elevated levels without supplementation may warrant GP review to exclude underlying conditions such as haematological disorders, liver disease, or renal impairment

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Furthermore, the amount of Ca 2+ released from the endoplasmic reticulum plays an important role in regulating apoptosis, as it signals the mitochondria, modulating autophagy suggesting a complex interplay between these pathways and necrosis, especially excitotoxicity-induced necrosis (Hyer-Hansen et al., 2007