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10.1017/S1461145712000739 28 BrudzynskiS

Microglia play a crucial role in orchestrating this phenotypic shift: upon activation, they release inflammatory mediators such as IL-1, TNF- and C1q, which induce a pro-inflammatory reactive astrocyte phenotype (often termed A1-like or neurotoxic reactive state) (Zhao et al., 2024

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Genetic Factors That Affect Your GLP-1 Response Not all weight loss plateaus are identicalyour genetic makeup influences how long you maintain responsiveness to GLP-1 therapy and which compound may work best
