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2015) reported significant improvements in learning and memory in rats administered 50 mg/kg/day of naringenin, highlighting its modulation of neuroprotective signaling pathways

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In response to energy status (level of ATP/ADP, NAD/NADH, TCA cycle enzymes and membrane potential), the activation of nuclear receptors (PPAR delta and EER) driven by PGC1 promotes the genes required for regulation of TCA cycle and ETC-proteins
