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10.1038/nrclinonc.2015.105 38 Cubillos-ZapataC.Avendao-OrtizJ.Hernandez-JimenezE.ToledanoV.Casas-MartinJ.Varela-SerranoA.et al (2017)

Spectrin dimer bonds that appear along the length of the molecules disassociate and reassociate (open and close) during RBC deformation

IGFBP-4 is generally inhibitory to IGF action and is regulated by the protease PAPP-A, which cleaves it to release bound IGF-1 in specific tissues
