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Integrated stress response A gene expression programme that can help the cell respond to a shortage of individual amino acids by increasing the expression of membrane transporters and other metabolic enzymes that restore homeostasis

We remain unaware of how specific localized reactive chemical signal inputs propagate along specific pathways involving defined mediators, leading to functional biological outputs

429 Subsequent studies found that FtMt overexpression reduced ROS and the contents of unstable iron in cytoplasm and mitochondria

Consistent with RNAseq and single cell proteomic analyses, we identified numerous metabolites and pathways that were differentially abundant in CD19.28-GLUT1 and HA.28-GLUT1 CAR-T cells compared to controls (Fig