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Digoxin inhibits sodium potassium adenosine triphosphatase (Na + /K + -ATPase) and in the myocardium it increases the intracellular level of sodium and calcium ions in the myocytes thus increasing cardiac contractile force [4]

This upregulation of the GH receptor potentiated the proliferative effects of growth hormone, as evidenced by increased cell proliferation (MTT assay) and proliferating cell nuclear antigen (PCNA) expression

New England Journal of Medicine 2013;368(2):14960

Thus, the dual advantage of consuming fewer calories while burning fats as an energy source may contribute to the lipotropic actions of choline