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In the phase III trial, AVP-825 showed an earlier onset and consistent responses across multiple migraine attacks compared with 100 mg oral sumatriptan, supporting the clinical value of breath-driven delivery designed to improve deposition beyond the nasal valve (Lipton et al., 2017

This dysfunction in opioid signaling constitutes a part of the dysregulation in the systems that modulate pain and underlines the complexity of fibromyalgia as a disorder that involves peripheral and central mechanisms [133,141]

Frontiers in Aging Neuroscience, 13 , 728360