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By inhibiting it, researchers are exploring a cascade of effects related to metabolic health, fat cell differentiation, and energy expenditure
Similarly, the small molecule activator 2-APQC effectively enhances SIRT3 activity, alleviating cardiac hypertrophy and myocardial fibrosis induced by isoproterenol (ISO)
NNMT inhibition increases NAD+ availability, which is known to support mitochondrial function, reduce fibrosis, and lower inflammation
