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Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: implications for age-related macular degeneration

doi: 10.1159/000407513

Early human trials in people with obesity found that daily AOD9604 was well tolerated and had a safety profile similar to placebo, with no major effects on glucose metabolism or IGF1, though weightloss results were modest and inconsistent
