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GlaxoSmithKline (GSK): "Paid a then-record $3 billion settlement in 2012 for promoting common prescription drugs like Paxil and Wellbutrin for unapproved uses, failing to report safety data for Avandia, and paying kickbacks to physicians. Pfizer Accrued around $7.8 billion in financial penalties, with a single 2009 settlement of $2.3 billion for illegal promotion of several drugs, including Bextra, marking the largest criminal fine in U.S

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This stability may explain why relatively low doses produce noticeable effects