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Interestingly, supplementing with NAC (600 mg/d for 4 wk) decreases GGT 25%, suggesting that increasing de novo synthesis decreases the need for GGT recycling.32 For those looking for a nonsupplemental solution, 500 mL of alcohol-free beer per day raises RBC glutathione 29%!33 There are many other examples of foods that increase glutathione

There is a virtual catalog of speculated root causes of neurodegenerative diseases (8)

Similarly, patients with active malignancy warrant careful consideration given theoretical concerns about angiogenic effects potentially affecting tumor growth, though preclinical evidence suggests context-dependent effects that may inhibit rather than promote tumor angiogenesis

In future, combination of this approach with 1H-MRS in the same subjects, and potentially during the same scanning session on combined PET-magnetic resonance platforms, might investigate dysfunction of synaptic versus non-synaptic GABA and glutamate in schizophrenia