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Description
Knockdown of COPZ1 leads to an increase of NCOA4, contributing to the degradation of ferritin, which leads to increased intracellular ferrous iron levels and eventually to ferroptosis
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In order to optimize the physicochemical characteristics of the cereblon ligands for the development of orally bioavailable PROTACs, Rankovics group (2024) conducted a comprehensive in vitro/vivo comparative study with different cereblon ligands analogs 157

Interaction of curcumin with manganese may compromise metal and neurotransmitter homeostasis in the hippocampus of young mice
