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Identifying defined AML subsets that may benefit from these strategies will be critical

Particularly noteworthy are the findings from studies utilizing IKK-deficient intestinal epithelial cells, which demonstrated enhanced apoptotic activity associated with increased expression and activation of the tumor suppressor protein P53, concomitant with reduced levels of pro-survival Bcl-2 family members

Murine models based on Tymp / /Upp / genes double knock-out have been developed to study MNGIE but displayed inconsistencies with the clinic likely due to differences in the deoxyribonucleoside metabolism between humans and mice (Haraguchi et al., 2002)