igf 1 lr3 cause cancer IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty Role of Insulin-like Growth Factor-1

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Arch Biochem Biophys 317:315323 Stoyanovsky DA, Goldman R, Jonnalagadda SS, Day BW, Claycamp HG, Kagan VE (1996) Detection and characterization of the electron paramagnetic resonance-silent glutathionyl-5, 5-dimethyl-1-pyrroline N-oxide adduct derived from redox cycling of phenoxyl radicals in model systems and HL-60 cells

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These findings align with reduced first-phase insulin secretion observed clinically, supporting the idea that early defects in stimulussecretion coupling precede measurable changes in mass