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Together, these issues make it challenging to determine which epigenetic alterations have real biological significance in depression or addiction

Diverse pharmacological and non-pharmacological approaches targeting neurobiological pathways other than neurotransmission have also been tested in mood disorders

Kainate receptors inhibit glutamate release via mobilization of endocannabinoids in striatal direct pathway spiny projection neurons

Reelin/RELN activates Rap1 to regulate actin cytoskeleton reorganization (via N-cofilin phosphorylation) and neuronal polarity, and promotes epithelial-mesenchymal transition by downregulating E-cadherin