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Statistical analysis In the in vitro alkaline comet assay, significant differences between control and treated cells were evaluated using the unpaired Welchs t -test, one-tailed (PCLiS, PHH and HepG2 cells), as equal variance was not assumed, or paired t -test, one-tailed (PRH, due to variability of each rat), using TIBCOs Statistica (StatSoft GmbH, Germany)

A: Yes, a valid prescription from a certified healthcare provider or veterinarian is required to purchase and use POLYBION INJECTION due to its specific indications and potential need for monitoring.

Reconstituted peptide stability

The mean percentage weight reduction in the retatrutide groups at 48 weeks were 8.7%, 17.1%, 22.8%, and 24.2% for the groups treated with 1 mg, combined 4 mg, combined 8, and 12 mg, respectively