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[18,19] While a rigorous characterization of senescent cells in vitro can generally be obtained by multiplexing three or more of these consensual markers, quantification of senescence in vivo is often complicated by the fact that tissue homogenates are composed of varied cell types and expression levels, among which senescent cells account for a relatively small percentage

doi: 10.1016/s1470-2045(18)30095-0 54 RatanapokasatitYLaisuanWRattananukromTPetchlorlianAThaipisuttikulISompornrattanaphanM

Ding L, Ley TJ, Larson DE, et al

This dual role in energy production and redox balance makes NAD+ essential for cellular health