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Description
Upon irradiation with visible light (410 nm), PPIX generates reactive oxygen species (ROS) 24 , which oxidizes Met to Met sulfoxide (MetO), thereby rebalancing noncovalent forces driving a morphological transition from nanofibers (NFs) to spherical nanoparticles (NPs)

Its onset of action is delayed since it takes weeks to reduce factor XI concentrations to sub-therapeutic levels, and it similarly takes weeks following the drug's discontinuation to achieve therapeutic factor XI concentrations

When controlling for potential confounding factors of alterations in serum lipids and glucose and for baseline values of cytokines, all findings, with the exception of IL-6, remained statistically significant

Int J Mol Sci 24(23):16567
