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Upon irradiation with visible light (410 nm), PPIX generates reactive oxygen species (ROS) 24 , which oxidizes Met to Met sulfoxide (MetO), thereby rebalancing noncovalent forces driving a morphological transition from nanofibers (NFs) to spherical nanoparticles (NPs)

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Its onset of action is delayed since it takes weeks to reduce factor XI concentrations to sub-therapeutic levels, and it similarly takes weeks following the drug's discontinuation to achieve therapeutic factor XI concentrations

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When controlling for potential confounding factors of alterations in serum lipids and glucose and for baseline values of cytokines, all findings, with the exception of IL-6, remained statistically significant

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Int J Mol Sci 24(23):16567

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