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Some of the common side effects of isotretinoin include: Dry skin and chapped lips Headaches Itchiness, rashes, hives, and general skin sensitivity Sensitivity to sun exposure may cause skin to burn more easily Nose bleeds caused by nasal passage dryness Body, joint, and muscle aches and pains Dry mouth and diminished saliva production Irritation of the eyes and surrounding areas Urinary tract or gastrointestinal symptoms Temporary hair thinning What to Expect When You Start Taking Accutane Before you start taking Accutane, your dermatologist will walk through your specific treatment plan step by step